q-lab-anglais

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axe2_fond-gris-bleu

Q-Lab / Leandro Quadrana

Presentation

In the Plant Quantitative Genomics and Epigenomics laboratory (Q-Lab) we investigate how new genetic and epigenetic variation are brought about and contribute to heritable phenotypic changes. In particular, we explore the potential role of de novo (epi)mutations, notably those generated by transposable element insertions, in the rapid adaptation of populations to drastic environmental changes, such as ongoing climate change. We use molecular, genetic, and computational approaches to characterise very large populations of experimental and wild-type plants.

Our lab is part of the Institute of Plant Science (IPS2) at the Paris-Saclay University, IPS2 is a major research hub in plant biology in France and Europe. It combines genomics, molecular and cellular biology, bioinformatics, biochemistry, genetics, and physiology to advance our understanding of the mechanisms controlling plant growth.

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Publications

2026
A functional atlas of transposon-encoded products and their integration into host networks. Borredá C, Vendrell-Mir P, Leduque B, Bueno Merino M, Oury C, Glab C, Colot V, Quadrana L. Nat Commun 2026. doi: 10.1038/s41467-026-76280-2
2026
Replication-uncoupled MET1/DNMT1 activity shapes inheritance of DNA methylation. Edera A, Larue M, Leduque B, Michaud C, Selles B, Boutserin S, Biocanin I, Serret J, Leblanc O, Jullien P, Berger F, Barneche F, Sasaki T, Ingouff M, Quadrana L. Cell Rep. 2026 Jul 28;45(7):117702. doi: 10.1016/j.celrep.2026.117702